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Pharmacological inhibition with the ataxia telangiectasia and Rad3-relevant protein serine/threonine kinase (ATR; also referred to as FRAP-similar protein (FRP1)) has emerged being a promising technique for cancer treatment that exploits artificial lethal interactions with proteins linked to DNA pro

It is thought that high amounts of MMR can positively add to the efficacy of chemotherapy [89,ninety], while a substantial number of preclinical and clinical info have demonstrated that inactivation of hMLH1 Despite the fact that DNA adduct development is considered the central step in the entire

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